Most programs that previously aired on the Hub Network moved here, including My Little Pony: Friendship is Magic. Thus, newer episodes of that show, starting with Season 5 (the first season of the show's second era), premiered on Discovery Family, on April 4, 2015.
The first full marathon of My Little Pony content aired in December 2016, comprising of all episodes from Seasons 1–6 and all four Equestria Girls films to date.
The series finale of My Little Pony: Friendship is Magic premiered on October 12, 2019, followed by the last Equestria Girls special, Holidays Unwrapped, on November 2, 2019.
In January 2020, Discovery Family phased out reruns of Season 7 of My Little Pony: Friendship is Magic, replacing it with weekly reruns of all My Little Pony (mostly Equestria Girls) specials. Season 2 left the air in April 2021, with Season 1 taking its place, and Season 6 returned to the channel in September 2021 after a two-year hiatus, while Season 3 phased out after December 2021, followed by Season 9 on weekends after March 2022.
Despite now being owned by Warner Bros. Discovery, Discovery Family still continues to air all of Hasbro's shows during daytime hours, including My Little Pony.
Besides My Little Pony: Friendship is Magic, feature-length films from most of America's six major film studios have also aired on Discovery Family, including a few Disney movies.